Showing posts with label isosorbide mononitrate. Show all posts
Showing posts with label isosorbide mononitrate. Show all posts

Saturday, 6 August 2016

Glyceryl Trinitrate Patch for Angina

Thought it would only be a matter of time, what with increasing angina episodes, needing to use my GTN spray almost daily and sometimes twice a day compared to once every week or two last year. And of course not totally unrelated to a new 99% blockage being found during an angiogram in May which could not be stented.

Now getting episodes out of the blue while sitting at the computer or watching TV and even, on occasion, when getting out of bed in the morning after a relatively, for me, good night's sleep. And have even started getting angina when exercising which rarely happened in the past.



Anyway, saw my GP, told him what has been happening and he suggested I contact my cardiologist about going on to a low dose, 24 hour Glyceryl Trinitrate patch which can be used in conjunction with my Isosorbide Mononitrate 60mg tablet which I take each morning - will double check this when I speak to my chemist as I using my GTN spray should angina issues continue although been told the same rules apply with the GTN spray - use up to twice and if it does not relieve an attack then call an ambulance. 


Lucky I can communicate with my cardiologist via email and he replied pretty quickly and agreed. So Monday, it is off to the chemist to get my first box of 5mg/24 hour patches. Just need to find out if I can wear these in the shower and when swimming. I do know you need to vary where you place them on your body to avoid skin irritation.


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Minitran patches (glyceryl trinitrate).

Minitran patches contain the active ingredient glyceryl trinitrate, which is a type of medicine called a nitrate. It is used to help the heart work more easily.

What is it used for?

  • Preventing angina attacks.
  • Minitran 5 patches can also be used to improve the blood supply to the site of an intravenous cannula. In people receiving medicines via an injection or drip (infusion) into a vein of the arm or leg, the patch is applied close to the cannula site to help keep the vein open.

How does it work?

Minitran patches contain the active ingredient glyceryl trinitrate, which is a type of medicine called a nitrate. It is used to help the heart work more easily.

Glyceryl trinitrate works by being converted in the body to a chemical called nitric oxide. This chemical is made naturally by the body and has the effect of making the veins and arteries relax and widen (dilate). When the blood vessels dilate in this way there is more space inside them and hence less resistance. This makes it easier for the heart to pump blood around the body.

Widening the veins also decreases the volume of blood that returns to the heart with each heartbeat. This makes it easier for the heart to pump that blood out again.

As a result of both these actions, the heart does not need as much energy to pump the blood around the body and therefore needs less oxygen.

Glyceryl trinitrate also widens the arteries within the heart itself, which increases the blood and oxygen supply to the heart muscle.

The pain of angina is caused by too little oxygen reaching the heart when its workload increases, such as during exercise. Glyceryl trinitrate improves the oxygen supply to the heart, as well as decreasing the amount of oxygen that the heart needs by making it easier for the heart to pump blood around the body. It can therefore be used to treat angina.

Minitran patches are used on a regular basis to help prevent angina attacks. The medicine is absorbed continuously from the patch through the skin and into the bloodstream.

For more information: http://www.netdoctor.co.uk/medicines/heart-and-blood/a7124/minitran-patches-glyceryl-trinitrate/

Sunday, 19 October 2014

Mild Mitral Valve Regurgitation

Over the years since my heart attack in 2007 I have had (and still have) numerous episodes of a fast, racing heart beat that sometimes feels like the heart is going to burst out of my chest. I have seen my cardiologist and have had tests and scans to check this out including 24 hour Holter Monitor tests.

Generally speaking, these fast heart beat events are not associated with any chest pain or discomfort. I have been told that Atrial Fibrillation (AF or Afib) and incidents of tachycardia and palpitations are not uncommon for someone like me with my heart history.

The American Heart Association has more information on Atrial Fibrillation and Arrhythmia here: http://www.heart.org/HEARTORG/Conditions/Arrhythmia/AboutArrhythmia/What-is-Atrial-Fibrillation-AFib-or-AF_UCM_423748_Article.jsp

Earlier this year, when I had another episode of 'racing' heart that happened 'on' and 'off' for a number of days I saw my cardiologist and did yet another holter test which showed no abnormality this was my third such test since 2009.

In 2012 after one of these events when I also had issues with mild chest pain and following a holter monitor test and echocardiagram, my cardiologist put me on Duride (Isosorbide Mononitrate) for the above and to help with angina. I still take this medication today.

Here are a few photos of me with the Holter monitor in February, 2014.




A couple of weeks after the holter test I had an echocardiogram which basically showed everything is normal but did reveal I had mild mitral valve regurgitation - was told nothing to be worried about but something to be aware of and to keep an eye on.

Bottom line: there was no explanation for the latest fast heart episode that happened out of the blue and not following exercise. Since then have had a number of similar incidents.

So when I saw this post on Facebook the other day it got my attention:

"October 11, 1958 - Cardiac surgeon Dr. Dwight McGoon performs the first mitral valve repair for mitral regurgitation. Today, Mayo Clinic cardiac surgeons use robotic surgery to surgically repair valves as an alternative to open-heart surgery. Surgeons operate between the ribs and don’t open up the breastbone (sternotomy), which results in less pain and quicker recovery. Robot-assisted minimally invasive mitral valve repair is now performed routinely at Mayo Clinic and has allowed hundreds of patients to be with their families the night of surgery and leave the hospital 3 days later, returning to work within a couple of weeks."



Dr Dwight McGoon

Tuesday, 14 October 2014

Still feeling my way around with this blog thingy - My Angina attack in May, 2014

So still trying to work out how this blog thingy works. Do I construct an historical timeline of what happened to me, before, during and after the heart attack in July, 2007? Or do I post about my heart event and intersperse this with things as they happen now on a day to day basis?

Thought about this yesterday whilst doing some exercise and have decided on the latter. Will post about issues as I recall them taking place and ongoing issues as they occur. I think this is the way to go and more REAL in the sense that it will help illustrate that when you have more than one health issue going on at the same time, 'fixing' one does not necessarily mean that all is hunky-dory.

For example: This morning I get up not feeling 100% - just one of those things that happens with my diabetes and can be the way I start a day once, twice or more times a week. Check my sugars as I do first thing each morning and they are 9 mmol/l (163.64 mg/dl) which is not fantastic but not all that bad given I don't sleep all that well which I now know impacts on my sugars.

I get on with it, have a yogurt and coffee after having earlier taken a shot of both Byetta and Lantus insulin for my diabetes which I do every morning before starting my day. I feel better, check what's happening on the internet and then get to preparing the food for our birds a daily routine which I have been doing on my own while Evelyn has been away this past week.



I take out Gilly (a long bill corella we adopted in 2008) from his room in our house where he spends nights and put him on the patio with the food I have prepared for all of our birds (and even wild birds like this king parrot who wasn't about to wait to be fed!).

This is a photo I took a few days ago. Gilly will sit in his cage watching me feed our other adopted birds and wildlife visitors before I put him into his aviary for the day.


Whilst feeding and watering our birds I start to feel unwell again - headache, bit of nausea, light chest pain and tingling down the left side of my arm/hand. Not uncommon for me, usually happens for no apparent reason like not exerting myself or exercising and been told a while ago I have unstable angina. More often than not, this can happen when I am sitting at my desk at my computer, however, this morning started soon after I got up from bed, improved then got worse as I was outside doing the birds.

Now when this all started a number of years ago I used to get all anxious and even would panic and would pick up the phone, make an appointment to see my cardiologist which a number of times resulted in my having various tests. Over the years since my heart attack I have had numerous stress tests and will talk more about these in a separate post. Even did a CT angiogram a couple of years ago which showed my stents were all okay.

Upshot of all this was being diagnosed with angina and being put on Duride (Isosorbide Mononitrate) to help manage it. I was also given a GTN Nitro spray to be used when an angina event occurred and I guess it would be fair to say that over the past few years I have managed my angina with these two meds.

 Nitrolingual (GTN) Spray

So when I felt unwell again this morning, I took a shot of my GTN spray, sat down for a bit to let it take effect and then went back to finishing up with the birds after feeling better.

I guess if there is a message I wish to share about the above it is one about the need for diabetics to recognize the interrelationship between poor sleep affecting sugar levels which in turn can affect the heart and bring on an angina attack.

Throw in additional issues that can arise for someone who has an endocrinological issue such as a thyroid condition, life can become that much more interesting with the continual battle to balance sugar and thyroid levels whilst managing a heart condition. Did I mention I have (had) Graves Disease? And if you have carotid artery blockages we are really getting into interesting territory.
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In May this year (2014) I had what turned out to be a pretty bad angina attack which landed me in hospital for two days and I learnt a lot from this incident about the relationship between sleep, diabetes and angina. I wrote the following about what happened on my Facebook page:

"On Tuesday, May 13 shortly after lunch I sat down at my desk and began feeling clammy and sweating profusely. I also had a touch of nausea, a queasy feeling and felt light headed but these lasted only a minute or two. In addition I had very slight pressure/ache down both sides of my neck going up to the lower jaw on both sides. I took my GTN spray as I thought this was just another angina attack but the sweating and pressure in my neck did not go away - usually within a few minutes of taking the spray any symptoms I have go away. The week before I had two angina attacks two days in a row, both of which were the worst to date, and my GP said the next time I have an attack to call an ambulance to get it checked out.

Because the sweating and neck ache persisted and given that  I have blocked carotids - up to 69% on the right side and up to 54% on the left - I decided that this time I would get this episode checked out and my wife phoned 000 to get an ambulance. On arrival the paramedics checked my blood sugars which came up with 3.8 and they said I may be having a Hypo/low. Now this was strange as just before I had lunch I had checked my blood sugar at 12.30pm and the reading was 5.2 so to be told I was having a Hypo less than two hours after eating a toasted chese and tuna sandwich and not feeling the Hypo symptoms I usually get had me confused.

The paramedics confirmed that I should be taken to hospital to be checked out, especially given the neck issues. They gave a tube of glucose to suck on which I couldn't tolerate so I opted to eat a bunch of my glucose laden jelly beans. En route to the hospital my sugar levels climbed to 6.2 and from memory, by the time I arrived at the hospital it was around 10.

In addition, they gave me four additional shots of GTN en route and by the time we arrived at emergency the ache on the left side had all but gone - the right side ache disappeared earlier after a couple of GTN shots."

From this episode I was reminded about having "silent" hypos at night while sleeping, something I had not thought about a lot.

I wrote more about this in a NOTE on my Facebook page and also highlighted the need for me (others) to be more vigilant in taking control of our own health, specifically when it comes to CHECKING OUR NUMBERS including sugar levels/HbA1C, blood pressure, thyroid/TSH levels, iron levels, etc. especially if you are someone like me with a number of issues going on at the same time. From this incident I also learnt about the need for me to address my poor sleep patterns and breathing issues both of which I was told during my hospital visit would  be impacting on my heart and affecting my angina.


My final comment in this note was: In summary, this week's events were a more than subtle reminder that I need to be more diligent and attuned to what is going on with my various issues and that to fail to do so could have dire consequences.

Here I am after being brought into hospital in May, 2014.